Investigating the influence of environmental factors on the incidence of renal disease with compositional data analysis using balances

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Investigating the influence of environmental factors on the incidence of renal disease with compositional data analysis using balances

Jennifer M. McKinley - Personal Name; Ute Mueller - Personal Name; Peter M. Atkinson - Personal Name; Ulrich Ofterdinger - Personal Name; Chloe Jackson - Personal Name; Siobhan F. Cox - Personal Name; Rory Doherty - Personal Name; Damian Fogarty - Personal Name; J.J. Egozcue, V. Pawlowsky-Glahn - Personal Name;

This research uses an urban soil geochemistry database of elemental concentration to examine the potential relationship between Standardised Incidence Rates (SIRs) of Chronic Kidney Disease (CKD) of uncertain aetiology (CKDu), and cumulative low level geogenic and diffuse anthropogenic contamination of soils with PTEs. A compositional data analysis approach was applied to determine the elemental balance(s) of the geochemical data showing the greatest association with CKDu. The research concludes that both anthropogenic and geogenic factors may be contributing influences to explain high incidences of CKDu, up to 12 times greater in some Super Output Areas (SOAs) than would be expected for the average population. The role of As, Cr, Cu, Pb, Sb and Mo was highlighted, which may be linked to anthropogenic sources such as historical industrial sources, atmospheric pollution deposition and brake emissions. Geogenic factors were shown to be important in areas with elevated relative concentrations of naturally occurring potentially toxic elements (PTEs).

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91 551.136 Perpustakaan BIG (Eksternal Harddisk) Available

Detail Information

Series Title: Applied Computing and Geoscience - Open Access
Call Number: 551.136
Publisher: Amsterdam : Elsevier., 2020
Collation: 7 hlm PDF, 1.529 KB
Language: Inggris
ISBN/ISSN: 2590-1974
Classification: 551.136
Content Type: text
Media Type: -
Carrier Type: -
Edition: Vol.6, June 2020
Subject(s): Geochemistry
Chronic kidney disease
Uncertain aetiology
Specific Detail Info: -
Statement of Responsibility: -

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Investigating the influence of environmental factors on the incidence of renal disease with compositional data analysis using balances
This research uses an urban soil geochemistry database of elemental concentration to examine the potential relationship between Standardised Incidence Rates (SIRs) of Chronic Kidney Disease (CKD) of uncertain aetiology (CKDu), and cumulative low level geogenic and diffuse anthropogenic contamination of soils with PTEs. A compositional data analysis approach was applied to determine the elemental balance(s) of the geochemical data showing the greatest association with CKDu. The research concludes that both anthropogenic and geogenic factors may be contributing influences to explain high incidences of CKDu, up to 12 times greater in some Super Output Areas (SOAs) than would be expected for the average population. The role of As, Cr, Cu, Pb, Sb and Mo was highlighted, which may be linked to anthropogenic sources such as historical industrial sources, atmospheric pollution deposition and brake emissions. Geogenic factors were shown to be important in areas with elevated relative concentrations of naturally occurring potentially toxic elements (PTEs).
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